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mouse: cdx2 cre  (Jackson Laboratory)

 
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    Jackson Laboratory mouse: cdx2 cre
    (A) The gracile nucleus (Gr, green) receives sensory inputs from lower body DRG afferents (cyan) and spinal projections (magenta). Retrograde virus injections into the VPL (right) labeled Gr VPL-projecting neurons (PNs). (B) Injection of cholera toxin β subunit (CTb, cyan) into the hindpaw glabrous skin labeled hindlimb afferents targeting the Gr (white dashed circle). Scale bar, 200 μm. (C) Advillin Cre ;Rosa26 LSL-Synaptophysin-GFP mice labeled synaptic terminals of primary afferents (cyan) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (D) <t>Cdx2</t> Cre ;Lbx1 FlpO ;Rosa26 LSL-FSF-Synaptophysin-GFP mice labeled terminals of spinal projections (magenta) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (E) In situ hybridization of excitatory (vGluT2, blue) and inhibitory (vGAT, red; GlyT2, green) neurons in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (F and G) Quantification of excitatory and inhibitory neuronal markers in the Gr core (F) and shell (G). (H) Strategy to label VPL-PNs (green) or inhibitory neurons (red). Inset: representative injection of AAV-retro GFP into the VPL. Scale bar, 1,000 μm. (I and J) Representative images of Gr VPL-PNs (I) (green), inhibitory neurons (J) (red), and NeuN + immunostaining of neurons (blue). Scale bar, 100 μm. (K and L) Quantification of VPL-PNs and inhibitory neurons in the Gr core (K) and shell (L) normalized to total NeuN.
    Mouse: Cdx2 Cre, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse%3A+cdx2+cre/pmc12093272-31-0-4?v=Jackson+Laboratory
    Average 90 stars, based on 1 article reviews
    mouse: cdx2 cre - by Bioz Stars, 2026-06
    90/100 stars

    Images

    1) Product Images from "The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states"

    Article Title: The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states

    Journal: Cell reports

    doi: 10.1016/j.celrep.2025.115556

    (A) The gracile nucleus (Gr, green) receives sensory inputs from lower body DRG afferents (cyan) and spinal projections (magenta). Retrograde virus injections into the VPL (right) labeled Gr VPL-projecting neurons (PNs). (B) Injection of cholera toxin β subunit (CTb, cyan) into the hindpaw glabrous skin labeled hindlimb afferents targeting the Gr (white dashed circle). Scale bar, 200 μm. (C) Advillin Cre ;Rosa26 LSL-Synaptophysin-GFP mice labeled synaptic terminals of primary afferents (cyan) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (D) Cdx2 Cre ;Lbx1 FlpO ;Rosa26 LSL-FSF-Synaptophysin-GFP mice labeled terminals of spinal projections (magenta) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (E) In situ hybridization of excitatory (vGluT2, blue) and inhibitory (vGAT, red; GlyT2, green) neurons in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (F and G) Quantification of excitatory and inhibitory neuronal markers in the Gr core (F) and shell (G). (H) Strategy to label VPL-PNs (green) or inhibitory neurons (red). Inset: representative injection of AAV-retro GFP into the VPL. Scale bar, 1,000 μm. (I and J) Representative images of Gr VPL-PNs (I) (green), inhibitory neurons (J) (red), and NeuN + immunostaining of neurons (blue). Scale bar, 100 μm. (K and L) Quantification of VPL-PNs and inhibitory neurons in the Gr core (K) and shell (L) normalized to total NeuN.
    Figure Legend Snippet: (A) The gracile nucleus (Gr, green) receives sensory inputs from lower body DRG afferents (cyan) and spinal projections (magenta). Retrograde virus injections into the VPL (right) labeled Gr VPL-projecting neurons (PNs). (B) Injection of cholera toxin β subunit (CTb, cyan) into the hindpaw glabrous skin labeled hindlimb afferents targeting the Gr (white dashed circle). Scale bar, 200 μm. (C) Advillin Cre ;Rosa26 LSL-Synaptophysin-GFP mice labeled synaptic terminals of primary afferents (cyan) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (D) Cdx2 Cre ;Lbx1 FlpO ;Rosa26 LSL-FSF-Synaptophysin-GFP mice labeled terminals of spinal projections (magenta) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (E) In situ hybridization of excitatory (vGluT2, blue) and inhibitory (vGAT, red; GlyT2, green) neurons in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (F and G) Quantification of excitatory and inhibitory neuronal markers in the Gr core (F) and shell (G). (H) Strategy to label VPL-PNs (green) or inhibitory neurons (red). Inset: representative injection of AAV-retro GFP into the VPL. Scale bar, 1,000 μm. (I and J) Representative images of Gr VPL-PNs (I) (green), inhibitory neurons (J) (red), and NeuN + immunostaining of neurons (blue). Scale bar, 100 μm. (K and L) Quantification of VPL-PNs and inhibitory neurons in the Gr core (K) and shell (L) normalized to total NeuN.

    Techniques Used: Virus, Labeling, Injection, In Situ Hybridization, Immunostaining



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    (A) The gracile nucleus (Gr, green) receives sensory inputs from lower body DRG afferents (cyan) and spinal projections (magenta). Retrograde virus injections into the VPL (right) labeled Gr VPL-projecting neurons (PNs). (B) Injection of cholera toxin β subunit (CTb, cyan) into the hindpaw glabrous skin labeled hindlimb afferents targeting the Gr (white dashed circle). Scale bar, 200 μm. (C) Advillin Cre ;Rosa26 LSL-Synaptophysin-GFP mice labeled synaptic terminals of primary afferents (cyan) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (D) <t>Cdx2</t> Cre ;Lbx1 FlpO ;Rosa26 LSL-FSF-Synaptophysin-GFP mice labeled terminals of spinal projections (magenta) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (E) In situ hybridization of excitatory (vGluT2, blue) and inhibitory (vGAT, red; GlyT2, green) neurons in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (F and G) Quantification of excitatory and inhibitory neuronal markers in the Gr core (F) and shell (G). (H) Strategy to label VPL-PNs (green) or inhibitory neurons (red). Inset: representative injection of AAV-retro GFP into the VPL. Scale bar, 1,000 μm. (I and J) Representative images of Gr VPL-PNs (I) (green), inhibitory neurons (J) (red), and NeuN + immunostaining of neurons (blue). Scale bar, 100 μm. (K and L) Quantification of VPL-PNs and inhibitory neurons in the Gr core (K) and shell (L) normalized to total NeuN.
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    Image Search Results


    (A) The gracile nucleus (Gr, green) receives sensory inputs from lower body DRG afferents (cyan) and spinal projections (magenta). Retrograde virus injections into the VPL (right) labeled Gr VPL-projecting neurons (PNs). (B) Injection of cholera toxin β subunit (CTb, cyan) into the hindpaw glabrous skin labeled hindlimb afferents targeting the Gr (white dashed circle). Scale bar, 200 μm. (C) Advillin Cre ;Rosa26 LSL-Synaptophysin-GFP mice labeled synaptic terminals of primary afferents (cyan) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (D) Cdx2 Cre ;Lbx1 FlpO ;Rosa26 LSL-FSF-Synaptophysin-GFP mice labeled terminals of spinal projections (magenta) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (E) In situ hybridization of excitatory (vGluT2, blue) and inhibitory (vGAT, red; GlyT2, green) neurons in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (F and G) Quantification of excitatory and inhibitory neuronal markers in the Gr core (F) and shell (G). (H) Strategy to label VPL-PNs (green) or inhibitory neurons (red). Inset: representative injection of AAV-retro GFP into the VPL. Scale bar, 1,000 μm. (I and J) Representative images of Gr VPL-PNs (I) (green), inhibitory neurons (J) (red), and NeuN + immunostaining of neurons (blue). Scale bar, 100 μm. (K and L) Quantification of VPL-PNs and inhibitory neurons in the Gr core (K) and shell (L) normalized to total NeuN.

    Journal: Cell reports

    Article Title: The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states

    doi: 10.1016/j.celrep.2025.115556

    Figure Lengend Snippet: (A) The gracile nucleus (Gr, green) receives sensory inputs from lower body DRG afferents (cyan) and spinal projections (magenta). Retrograde virus injections into the VPL (right) labeled Gr VPL-projecting neurons (PNs). (B) Injection of cholera toxin β subunit (CTb, cyan) into the hindpaw glabrous skin labeled hindlimb afferents targeting the Gr (white dashed circle). Scale bar, 200 μm. (C) Advillin Cre ;Rosa26 LSL-Synaptophysin-GFP mice labeled synaptic terminals of primary afferents (cyan) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (D) Cdx2 Cre ;Lbx1 FlpO ;Rosa26 LSL-FSF-Synaptophysin-GFP mice labeled terminals of spinal projections (magenta) in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (E) In situ hybridization of excitatory (vGluT2, blue) and inhibitory (vGAT, red; GlyT2, green) neurons in the Gr core (solid white line) and shell (dashed white line). Scale bar, 100 μm. (F and G) Quantification of excitatory and inhibitory neuronal markers in the Gr core (F) and shell (G). (H) Strategy to label VPL-PNs (green) or inhibitory neurons (red). Inset: representative injection of AAV-retro GFP into the VPL. Scale bar, 1,000 μm. (I and J) Representative images of Gr VPL-PNs (I) (green), inhibitory neurons (J) (red), and NeuN + immunostaining of neurons (blue). Scale bar, 100 μm. (K and L) Quantification of VPL-PNs and inhibitory neurons in the Gr core (K) and shell (L) normalized to total NeuN.

    Article Snippet: Mouse: Cdx2 Cre , Jackson Laboratories , Jax#009350.

    Techniques: Virus, Labeling, Injection, In Situ Hybridization, Immunostaining

    KEY RESOURCES TABLE

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    Figure Lengend Snippet: KEY RESOURCES TABLE

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    Article Title: Cell-type specific responses to interleukin-1 control microbial invasion and tumor elicited inflammation in colorectal cancer

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    Article Snippet: Mouse: CDX2Cre , Jackson Laboratories , B6.Cg-Tg(CDX2-cre)101Erf/J Stock No: 009350; CDX2P-NLS Cre.

    Techniques: Virus, Recombinant, Injection, Enzyme-linked Immunosorbent Assay, Reverse Transcription, SYBR Green Assay, Sequencing, Software